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dc.creatorCastillo Rivas, Christian Raul
dc.creatorDuaso Inostrosa, Juan Gabriel
dc.creatorKemmerling Weis, Ulrike
dc.date.accessioned2016-12-27T21:49:41Z
dc.date.available2016-12-27T21:49:41Z
dc.date.issued2011
dc.identifier.isbn9789533077543
dc.identifier.isbn978-953-51-0194-9
dc.identifier.urihttp://hdl.handle.net/10533/165308
dc.description.abstractAmerican trypanosomiasis, or Chagas disease, a zoonosis caused by Trypanosoma cruzi (T. cruzi), is endemic in Latin America and ten million people are estimated to be infected (Araújo et al 2009, World Health Organization (WHO), 2010). In the past decades, Chagas disease has been increasingly detected in other non-endemic countries such as Canada, the United States of America, Australia, Japan and in Europe. The presence of Chagas disease outside Latin America is the result of population mobility, notably migration, but also from travelers returning from Latin America and in adopted children (Schmunis, 2007). Subsequent transmission occurs through transfusion, transplantation or vertical routes. More than 10 000 deaths are estimated to occur annually from Chagas disease; its incapacitating effects and mortality are ones of the biggest public-health problems in Latin America. The 10-year mortality rate may range from 9% to 85%, depending on the extent of the cardiac damage induced by the parasite (WHO, 2010). Chagas disease manifests first with an acute phase, lasting for about 2 months, characterized by high parasitaemia. Most cases are asymptomatic or present nonspecific symptoms. Then, it turns into a chronic phase, the parasites hiding in target tissues, especially in the heart and digestive muscles (WHO, 2010) and in case of pregnancy, also in the placenta (Bittencourt, 1976). During the chronic phase, different clinical manifestations may be observed: 1) the cardiac form; 2) the digestive form, particularly enlargement of the esophagus and the colon; and 3) a mixed form (cardiac plus digestive) (Rassi, 2006).
dc.language.isoeng
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI 2.0
dc.titleMECHANISM OF CONGENITAL CHAGAS DISEASE: EFFECTIVE INFECTION DEPENDS ON THE INTERPLAY BETWEEN TRYPANOSOMA CRUZI AND THE DIFFERENT TISSUE COMPARTMENTS IN THE CHORIONIC VILLI OF THE HUMAN PLACENTA
dc.typeCapitulo de libro
dc.bibliographicCitation.stpage149
dc.bibliographicCitation.endpage164
dc.identifier.folio11080166
dc.description.conicytprogramFONDECYT
dc.relation.projectidinfo:eu-repo/grantAgreement/Fondecyt/11080166
dc.relation.setinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93479
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.type.driverinfo:eu-repo/semantics/bookPart
dc.description.shortconicytprogramFONDECYT
dc.title.libroRECENT ADVANCES IN RESEARCH ON THE HUMAN PLACENTA
dc.creator.libroJing, Zheng
dc.description.libropages438
dc.publisher.editorialINTECH


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