Show simple item record

dc.creatorBattiprolu, Pavan K.
dc.creatorDel Campo, Andrea
dc.creatorDiaz Araya, Guillermo Antonio
dc.creatorFerdous, Anwarul
dc.creatorGarcia Nannig, Lorena Del Pilar
dc.creatorGatica, Damian
dc.creatorGuillette, Thomas G.
dc.creatorHill, Joseph A.
dc.creatorLavandero Gonzalez, Sergio Alejandro
dc.creatorLopez Crisosto, Camila Paz
dc.creatorMorales Campos, Pablo Esteban
dc.creatorNemchenko, Andriy
dc.creatorParedes, Felipe
dc.creatorPedrozo Cibils, Zully Rocio
dc.creatorTorrealba Cardenas, Natalia Belen
dc.creatorTroncoso Cotal, Rodrigo Hernan
dc.creatorVasquez Trincado, Cesar Alonso
dc.date.accessioned2016-12-27T21:49:18Z
dc.date.available2016-12-27T21:49:18Z
dc.date.issued2012
dc.identifier.isbn978161942266-7 
dc.identifier.urihttp://hdl.handle.net/10533/165198
dc.description.abstractInsulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.
dc.language.isoeng
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI 2.0
dc.relation.ispartofseriesCELL BIOLOGY RESEARCH PROGRESS
dc.titleREGULATION OF AUTOPHAGY BY INSULIN/IGF-1 SIGNALING PATHWAYS
dc.typeCapitulo de libro
dc.countryESTADOS UNIDOS DE AMERICA
dc.bibliographicCitation.stpage181
dc.bibliographicCitation.endpage194
dc.identifier.folio3110114
dc.description.conicytprogramFONDECYT
dc.relation.projectidinfo:eu-repo/grantAgreement/Fondecyt/3110114
dc.relation.setinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93479
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.type.driverinfo:eu-repo/semantics/bookPart
dc.description.shortconicytprogramFONDECYT
dc.title.libroAUTOPHAGY: PRINCIPLES, REGULATION AND ROLES IN DISEASE
dc.creator.libroGorbunov, Nikolai
dc.description.libropages371
dc.publisher.editorialNOVA PUBLISHERS


Files in this item

FilesSizeFormatView

There are no files associated with this item

This item appears in the following Collection(s)

Show simple item record