Show simple item record

dc.creatorCarreño Marquez, Leandro Javier
dc.creatorKalergis Parra, Alexis Mikes
dc.creatorRiedel Soria, Claudia Andrea
dc.date.accessioned2016-12-27T21:47:53Z
dc.date.available2016-12-27T21:47:53Z
dc.date.issued2011
dc.identifier.isbn978-1-60761-869-0
dc.identifier.isbn978-1-60761-868-3
dc.identifier.urihttp://hdl.handle.net/10533/164753
dc.description.abstractAutoimmune diseases develop as a result of an unbalanced adaptive immunity that targets self-antigens and causes destruction of healthy host tissues. Maintenance of peripheral immune tolerance to self- antigens is mainly mediated by dendritic cells (DCs), professional antigen-presenting cells that modulate the activation of T cells. Due to their key role as regulators of adaptive immunity, identification of means of enhancing DC tolerogenic capacity and therapeutic potential is a priority goal to reduce autoimmune disease burden in an antigen-specific manner. Our findings suggest novel approaches to enhance DC capacity to induce self-tolerance and reduce the severity of autoimmune disorders. Specifically, we have shown, both in vitro and in vivo, that NF-?B blockade on DCs by andrographolide or rosiglitazone can significantly enhance the tolerogenic capacity of DCs. Furthermore, we have observed that expression ratio of the activating Fc?RIII or the inhibitory Fc?RIIb is determinant for the tolerogenic potential of DCs. In this chapter, we describe the procedures to produce tolerogenic DCs and explain the potential therapeutic use of two NF-?B inhibitors for the treatment of autoimmune disease models, such as experimental autoimmune encephalomyelitis (EAE) and systemic lupus erythematosus (SLE) in mice. Therefore, our studies support the notion that Fc?Rs and NF-?B can be considered as pharmacological targets to increase the capacity of DCs to induce or restore self-tolerance and decrease inflammatory damage to self-tissues.
dc.language.isoeng
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI 2.0
dc.relation.urihttp://www.springer.com/us/book/9781607618683
dc.titleINDUCTION OF TOLEROGENIC DENDRITIC CELLS BY NF-?B BLOCKADE AND FC? RECEPTOR MODULATION
dc.typeCapitulo de libro
dc.countryREINO UNIDO DE GB E IRLANDA DEL NORTE
dc.bibliographicCitation.stpage339
dc.bibliographicCitation.endpage353
dc.identifier.folio1110397
dc.description.conicytprogramFONDECYT
dc.relation.projectidinfo:eu-repo/grantAgreement/Fondecyt/1110397
dc.relation.setinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93479
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.type.driverinfo:eu-repo/semantics/bookPart
dc.description.shortconicytprogramFONDECYT
dc.title.libroSUPPRESSION AND REGULATION OF IMMUNE RESPONSES. METHODS AND PROTOCOLS
dc.creator.libroAnegon Krecl, Ignacio
dc.creator.libroCuturi, Maria Cristina
dc.description.libropages260
dc.publisher.editorialSPRINGER


Files in this item

FilesSizeFormatView

There are no files associated with this item

This item appears in the following Collection(s)

Show simple item record